Tuesday, 2nd December Australasian Society for Immunology Annual Scientific Meeting 2014

• Metabolic interactions in the tumor microenvironment - Erika L Pearce
• Molecular insights into the regulation of T cell signalling with single molecule localisation microscopy - Katharina Gaus
• Innate Immunity in the Central Nervous System and Neurodegeneration - Marco Colonna
• Two waves of T cell negative selection in the thymus - Stephen R Daley

• Transplantation tolerance by design - Qizhi Tang
• Genetic control of tissue homeostasis & its impact for autoimmune disease - Shane Grey
• The transcriptional regulator Blimp1 and its homologue Hobit cooperatively regulate tissue-residency of lymphocytes - Axel Kallies
• PI16: a novel biomarker on human Treg subsets which identifies defective Treg in Type 1 diabetes. - Simon C Barry

• Cellular dynamics of adaptive immune responses in the lymph node - Takaharu Okada
• Title to be provided - Jacques Banchereau
• Elucidation of T cell fate control by time lapse imaging and quantitative microscopy - Sarah Russell
• Multi-lineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus. - Ann Chidgey

• Scrutinizing the magnitude and rhythm of ligand-induced intracellular calcium flux in T lymphocytes to deduce the strength of stimulus - Susan N Christo
• Generation of TH22 cells identifies a unique transcriptional profile - Maximilian Plank
• Neuroserpin: The presence of a neuronal modulator at the immunological synapse. - Evert Jan Loef
• The role of the transcription factor Bach2 during thymic and peripheral differentiation of Foxp3⁺ regulatory T cells - Christoph Thelemann
• Temporal regulation of T cell priming and cellular dynamics during peripheral viral infection - Jyh Liang Hor
• Roquin binds microRNA-146a and Argonaute2 and regulates microRNA homeostasis in T cells  - Monika Srivastava
• Understanding the interplay between STAT6 and GATA3 during the acquisition of Granzyme A in CD8⁺ T cells - Michelle Nguyen
• FOXP3 orchestrated gene regulaton in  human regulatory T cells. Genome wide approaches for mapping the transcriptome and discovering biomarkers - Kristen Malatesta

• Understanding the dynamics and TCR profiling of human follicular T cells elicited by influenza virus immunization and infection. - Oanh Nguyen
• Microparticles from M. tuberculosis infected human macrophages contain elevated type I interferon inducible proteins including ISG15 and IFITs - Nathan J Hare
• Hallmark inflammation and interferon responses during rhinovirus 1B infection are mediated by CCL7 and IRF7 - Jason Girkin
• Australia’s first CyTOF: mass and fluorescence cytometry of complex bone marrow system mobilization during viral encephalitis - Thomas M Ashhurst
• Distinct apoptotic pathways control regulatory T cell survival and death during chronic viral infection - Charis Teh
• Interferon-α reduces isotype diversification of IgG without inhibiting plasmablast induction - Sonia Fernandez
• Resident-memory CD4+ T cells are retained in skin by hair follicle-derived chemkoines following skin damage - Nicholas Collins
• The incomplete activation and decline in circulating CD1c (BDCA-1) dendritic cells in falciparum and knowlesi malaria, including a first blood-stage infection. - Jessica R Loughland

• A critical role for desmoglein-2 (DSG2) in melanoma vasculogenic mimicry - Claudine S Bonder
• NKT cells and MAIT cells in patients with cancer - Stuart P Berzins
• Simple and effective tumour immunotherapy using intratumoural Complete Freund's Adjuvant. - Aude M Fahrer
• Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced anti-tumor T cell responses - Paul A Beavis
• Characterization of the inactivation experienced by T cells after adoptive cell therapy into mice bearing a tumour load above a critical density threshold   - Gabriela Segal
• B cells have both effector and regulatory functions in anticancer immunity. - Thomas V Guy
• Combination therapy for metastatic melanoma: an investigation of GD2-specific chimeric antigen receptor T cells and MAPK-pathway targeted therapy - Tessa Gargett
• Haematopoietic cell kinase activation enhances colorectal cancer development and progression by promoting alternative macrophage polarisation - Ashleigh Poh

• Aeroallergen sampling in an experimental animal model for tolerance / atopy     - Jonatan Leffler
• TLR4 is critical for upregulation of uterine activation and inflammatory genes associated with on time labour - Lachlan M Moldenhauer
• Male IgG seroconversion to urogenital chlamydial infection exacerbates pathology in females - Charles W Armitage
• RelB deficiency promotes allergic airway inflammation in mice - Prema Mono Nair
• Vitamin D₃ metabolites repress IgE-dependent mast cell activation - Natasha Kolesnikoff
• Peripheral T cell subsets in cystic fibrosis - Emily Mulcahy
• IL-25 regulates host-microbial mutualism in the intestine - Catherine Plunkett
• Lung macrophage heterogeneity as a translatable avenue for human immunophenotyping - Mubing Duan

Please view the program at http://www.asi2014.org/workshops/hlda/

• MR1-reactive T cells: TCR variation and functional implications - Nicholas A Gherardin
• Common HLA-DR specific human memory CD4+ T-cells identified in both antigen-stimulated culture co-expressing CD25 with CD134 (OX40), and standardized methodology using molecular clonotype analysis - David van Bockel
• Antigen presentation during influenza virus infection - Ting Wu
• Characterisation of major allergens in Australian mollusc species - Jodie Abramovitch
• Effect of thermal processing on IgE cross-reactivity between Australasian crustacean species in shellfish-allergic patients - Jodie Abramovitch
• Epicutaneous application of Fingolimod attenuates allergic inflammation - Claudine Bonder
•  House dust mites’ allergens (Der p 1 and Der f 1) in Birjand, a small city of Iran - Mohammad Fereidouni
• Chlamydia pneumoniae infection of dendritic cells induces differential responses in acute and stable asthmatic patients - Danica Hickey
• Developing a mouse model to understand the cellular mechanisms underlying increased disease severity in allergic asthmatic women during pregnancy - Kyle T Mincham
• The role of viral TNFR (crmD) in the host response to poxvirus infection - Zahrah Al Rumaih
• A novel cytometer optimisation protocol for the generation of high-quality and reproducible polychromatic flow cytometry data from a range of panels - Thomas M Ashhurst
• Modulation of MHC class I expression by human cytomegalovirus encoded IL-10 - Selmir Avdic
• Characterisation of immunological responses in chickens infected with influenza H5N6, a new highly pathogenic avian influenza type - Andrew G D Bean
• Wnt pathway activation in sepsis: from patient associations to functional studies - Antje Blumenthal
• Post-infection airway repair mechanisms protect against Hookworm - Tiffany Bouchery
• Experimental infection with P. falciparum generates two distinct circulating microRNA expression profiles in naive subjects - Julie G Burel
• Modulation of natural killer cell responses by varicella zoster virus - Tessa M Campbell
• Investigation of the protein content of plasma microparticles released during experimental cerebral malaria - Valery Combes
• The chemokine receptor CCR6 is important for the induction of effective memory CD8+ T cell responses to influenza A infection - Kevin Aaron Fenix
• Opsonising antibodies to P.falciparum merozoites associated with immunity to clinical malaria - Danika L Hill
• The recruitment of T-cell populations from non-draining lymph nodes to the adaptive immune response during viral encephalitis. - Caryn van Vreden
• Advanced polychromatic (6-18 colour) flow cytometry panel design: an update on best practices and holistic solutions to practical considerations - Thomas Ashhurst
• Bee venom phospholipase A2 suppresses allergic airway inflammation through the increased presence of regulatory T cells in ovalbumin-induced asthma model - Hyunjung Baek
• Modulating innate immune responses to biomaterial-induced inflammation - Susan N Christo
• A murine transcriptional signature of experimental COPD is comparable to Human disease - Andrew Deane
• Discrete roles for ABC transporters in endotoxin-induced monocytic microparticle release - Georges E. Grau
• Functional characterization of monocyte derived macrophage phenotypes for their role in atherosclerosis - Eva Hadadi
• Mono-Net: A comprehensive network tool for assessing inflammatory signalling in mononuclear phagocytes - David G Hancock
• Perturbations in adhesion molecules and receptors in moderate versus severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients  - Sharni L Hardcastle
• Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes pulmonary inflammation and emphysema-like alveolar enlargement in experimental COPD - Tatt Jhong Haw
• The Bromodomain inhibitor I-BET151 prevents disease pathogenesis in an experimental model of chronic obstructive pulmonary disease (COPD). - Bernadette Jones
• Fibulin-1 plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD) - Gang Liu
• Infection and inflammation induce bone marrow changes altering hematopoiesis and structural cell populations - Steven Maltby
• Enigmatic role of the inflammogen complement C4 in autoimmune disease - Audrey A Margery-Muir
• Mechanism of Interferon Stimulated Gene induction in macrophages and their relative importance as restriction factors for HIV replication - Abdulltateef Alshehri
• Functional and structural characterisation of Type-2 NKT cell receptors - Tamara Hilmenyuk
• Nontranscriptional regulation of NLRP3 inflammasome signaling by IL-4 - Inhwa Hwang
• The interaction of Langerhans and dermal dendritic cells with Herpes Simplex Virus-1 in human skin - Min Kim
• TMEM203 is a novel regulator of TLR mediated inflammatory signalling - Endre Kiss-Toth
• P2X7 receptor blockade reduces the concentration of serum human IFN-γ in a humanised mouse model of graft-versus-host disease - Nicholas Geraghty
• Interleukin-5 therapy prevents chronic allograft rejection by induction of T regulatory cells - Bruce M Hall
• The mechanism for donor antigen presenting cells to augment acute graft-versus-host disease - Motoko Koyama
• A new multiphoton technique for imaging transplanted islets under the kidney capsule in live mice - Michael P Kuligowski
• Investigating the cells responsible for skin graft rejection using multiphoton microscopy - Michael P Kuligowski
• Autophagy is critical for the survival of regulatory T cells in the periphery - Laetitia Le Texier
• Revealing Bm1 as a biomarker and regulator of pro-angiogenic progenitor cell function - Kate A Parham
• Test of transplant tolerance by in vitro assay of CD4⁺CD25⁺T cells - Catherine Robinson
• Investigating the human immune response in humanised mice with and without Graft-Versus-Host Disease (GVHD) - Debbie Watson
• Aging induces compartmentalised changes in dendritic cells - Joanne K Gardner
• Are chemotherapy-resistant tumours susceptible to immunotherapy? - Connie Gilfillan
• Macrophages polarised into a pro-inflammatory phenotype induce endothelial cell activation. - Sarah J Henn
• Differential risk of immunosuppressive drugs to squamous cell carcinoma development: a role for memory T-cells? - Ji-Won Jung
• The percentage of iNKT cells among other immune cells at various clinical stages of laryngeal cancer - Janusz Klatka
• Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia. - F Mackay
• Colorectal tumour associated macrophages are more pro-inflammatory than adjacent control bowel tissue macrophage populations. - Sam Norton
• Novel cancer immunotherapy using Complete Freund’s Adjuvant - Christina Salmon
• Genetic markers for resilience and susceptibility to Johne’s disease in red deer (cervus elaphus) - Liam Brennan
• Chicken IFNλ as an adjuvant - Daniel S Layton
• A natural P452S mutation, equivalent in position to the loss-of-function P451L mutation in murine P2X7, does not alter canine P2X7 function - Ronald Sluyter
• Viral replicative capacity drives induction of long-lived humoral immunity - Preethi Eldi
• Novel roles of IL-21 in B cells during pre germinal center phase of a T cell dependent response as revealed by a model mouse system. - Ivan Fung
• Primary immunodeficiencies reveal quantitative and qualitative consequences of single gene mutations on the generation and function of human T follicular helper cells - Stuart G Tangye
• Chromatin Conformation Capture: Mapping the direct interactions of FOXP3 and its regulated targets over short and long distances - Simon C Barry
• The role of T-cell receptor affinity in CD4⁺ T-cell activation and differentiation. - Nayan Bhattacharyya
• Characterisation and functional analysis of factors that define tissue-resident memory T cells and contribute to their sessile phenotype - Asolina Braun
• MALT1 is an intrinsic regulator of Tregs - Anne Bruestle
• Dissecting CD8+ T cell recruitment into the immune repertoire - Jesseka Chadderton
• Characterisation of mucosal-associated invariant T cells in wild-type mice using MR1-antigen tetramers. - Hui-Fern Koay
• The role of CCR2 and CCR6 in γδT17 recruitment to the CNS during EAE - Duncan R McKenzie
• MR1 restricted T cells undergo expansion in response to acute exercise - Samy Sakkal
• Decoding ligand specificity within the killer cell immunoglobulin-like receptor family - Julian P Vivian
• Understanding lymph node vasculature on a global scale – Combined 3D imaging and computational analysis of blood and lymphatic networks across entire lymph nodes - Inken Kelch
• Repeated exposure to seminal fluid expands uterine antigen presenting cell and Treg cell populations in mice  - Lachlan M Moldenhauer
• Intravital imaging of skin-resident memory CD8⁺ T cell recall following Herpes Virus infection - Ali ZAID

• Title to be provided - Barbara Fazekas de St Groth