Thursday, 4th December Australasian Society for Immunology Annual Scientific Meeting 2014

• Regulatory B cells (B10 cells) in health and disease - Tom Tedder
• Title to be provided - Virginia Pascual
• Antigen-presenting cell–targeted antigen expression: insights into requirements and mechanisms of steady-state and therapeutic T-cell tolerance. - Raymond Steptoe
• Inflammasome defects in autoimmune NZB mice - Katryn J Stacey

• A vaccination strategy that exploits lipid recognition and elicits long lasting immunity to bacterial polysaccharides - Gennaro De Libero
• Using mass cytometry and tetramer analysis to dissect mechanisms of immune responses - Helen M McGuire
• Genome wide mapping of epigenetic signatures identify novel enhancer elements that underpin virus-specific CD8+ T cell differentiation - Stephen J Turner
• IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8⁺ T cells in experimental cerebral malaria - Andrew Mitchell

• Diet, metabolites, and ‘western lifestyle’ inflammatory diseases - Charles R Mackay
• Dissecting the function of human CD4⁺ T cells in autoimmune diabetes - Stuart I Mannering
• Whole exome sequencing in early-onset cerebral SLE identifies a pathogenic variant in TREX1. - Julia I Ellyard
• Beta cell defects contribute to diabetes susceptibility in Non-Obese Diabetic mice  - Adrian Liston

Dr Nick Fletcher & Dr Tiffany Bamford

• ADAMTS5 - A critical enzyme in T cell mediated immune responses - Meagan McMahon
• Plasmodium berghei ANKA sporozoite infection induces the formation of liver-associated CD8 T cells that resemble tissue resident memory cells - Daniel Fernandez Ruiz
• Role of NK cells in IFN-ɛ-mediated protection against female reproductive tract infection - Jemma Mayall
• Treatment with immune-modifying microparticles in West Nile virus infection suggests a common precursor for inflammatory monocytes and plasmacytoid dendritic cells - Victoria R Jones
• The role of PD-1 in viral predisposition to secondary bacterial pneumonia. - Alexandra Brown
• PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria - Joshua M Horne-Debets
• HSV infects dendritic cells via a pH-dependent endocytic pathway, however, cross-presentation of UV-inactivated HSV occurs largely via the proteasome - Kirstie Bertram
• Understanding the mechanisms that result in death of DCs during Salmonella infection - Chenying Yang

• How deletional and non-deletional tolerance mechanisms integrate to prevent fatal autoimmune diseases - Daniel Gray
• Loss of the BAFF receptor TACI protects against BAFF-driven autoimmune disease. - William A Figgett
• Genetic control of regulatory T cell function in type 1 diabetes - Emma E Hamilton-Williams
• Identification of candidate risk genes linking inflammation and fibrosis in neonatal lupus - Joanne H Reed
• Rare variants in BANK1 and interacting partners in systemic lupus erythematosus - Simon H Jiang
• Apics deficiency reveals a role for lncRNA in dendritic cell function and autoimmune disease - Edward P F Chu
• Gpr65 deficiency exacerbates experimental autoimmune encephalomyelitis, altering CD4⁺ helper T cell and NKT cell cytokine production - Rushika Wirasinha
• Development of anti-islet autoimmunity is restricted to early life in NOD mice - Gaurang Jhala

• Defining T cell help as a means to amplify innate immune signals in dendritic cells - Sammy Bedoui
• Aberrant polymerized actin triggers inflammasome activation and autoinflammatory disease that is dependent on IL-18, not IL-1β - Seth L Masters
• CD16+ monocytes: their potential role in antibody immunotherapy for cancer. - Siew Cheng Wong
• High salt (NaCl) reduces the activation and function of IL-4 IL-13 stimulated macrophages - Katrina Binger
• The liver- a novel immune surveillance site for the peritoneal cavity - Frederic Sierro
• Investigating the “M” in WHIM syndrome - Sapna Devi
• Neutrophils egress from the site of bacterial inflammation to the lymph nodes to orchestrate adaptive immune responses - Henry R Hampton
• Integration of innate and adaptive immunity to murine CMV by TLR7, TLR9 and the inflammasome - Shamika SM Moore

• A novel mutation in CVID patients - Vanessa Bryant
• Dynamic responses by lymphoid stromal cells controls lymph node hypertrophy following infection - Julia L Gregory
• Consequences of loss-of function mutations on the function of human STAT3 - Simon J Pelham
• Identifying and tracking autoimmune-inducing T cell clones in Aire^-/- Cblb^-/- mice.  - Mandeep Singh
• Nuclear PKC-θ and permissive chromatin coordinate transcriptional memory responses in human T cells - Jasmine Li
• Loss of TRAF2 impairs CD4+ T cell effector function and prevents islet allograft rejection. - Jeanette E Villanueva
• The role of IL-21 signalling in the germinal centre response to T-dependent antigen - Christoph Jandl
• DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity - Scott N Mueller

• SLC16A10 deficiency reveals a role for aromatic amino acid transport in immune cell function and autoimmune diabetes - May Alsayb
• Molecular hallmarks in myasthenia gravis - Claudia Barzago
• Autoantibody production and affinity maturation is regulated by a short locus on mouse chromosome 12 - Roxanne Collin
• A qualitative and quantitative survey of T cell Epitopes in Type 1 Diabetes  - Kailin Giam
• IL-21 stimulates cytotoxicity in CD8+ T lymphocytes within pancreatic islets. - Kate L Graham
• Cross-reactivity of a ubiquitous barley-specific T cell population accounts for the immuno-stimulatory effects of oats in coeliac disease - Melinda Hardy
• Immunostimulatory CpG motifs in the human genome. - Ernesto Hurtado
• Clinical efficacy of Mesenchymal stem cells and Mesenchmal stem cells- derived neural progenitors in experimental autoimmune encephalomyelitis - Eskandardar Kamali Sarvestani
• IL-31: New cytokine in the pathogenesis of RA - Eskandar Kamali Sarvestani
• Comparing and optimizing the use of atypical antipsychotic agents to treat multiple sclerosis - Anne Camille La Flamme
• Coxsackievirus B4 induced pancreatic inflammation is associated with a unique type 1 IFN signature - Claudia Loetsch
• Intersection of MS susceptibility gene and EBV immune pathways - Fiona McKay
• The serine protease granzyme A controls activation of innate immunity and type I interferon production in non-obese diabetic mice - Hong Sheng Quah
• Immunoglobulin G Fc-Sialylation is associated with disease remission in CIDP - Isaak Quast
• Blocking IFN-gamma signaling with a Jak1/2 inhibitor alters diabetes progression in mouse models of autoimmune diabetes - Nicholas A Scott
• IL-6 induced STAT in circulating CD4+ lymphocytes is a marker for early anti-citrullinated peptide antibody-negative rheumatoid arthritis. - Mamdouh Sedhom
• IL-10 receptor and endoplasmic reticulum stress impairs STAT3 activation in type 1 diabetes patients and their first degree relatives - Mamdouh Sedhom
• Expansion of influenza haemagglutinin-specific CD4+ regulatory T cells from peripheral blood of a HLA-DRB1*04:01+ healthy donor - Jennifer R Tyler
• Effect of M.tuberculosis cell wall associated protein rRv3083 on Toll like receptor expression in human macrophages - Iti Saraav
• Circulating clones of Community-Acquired Methicillin-Resistant Staphylococcus aureus (CA-MRSA) in Western Australia in the past 11 years (2002-2013) - Abdul AM Setiawan
• Age-related differences in CD25⁺Foxp3⁺CD127^low CD4 regulatory T cell activation in uncomplicated Plasmodium knowlesi malaria. - Jessie C Spargo
• Evaluation of a novel passive immunotherapy approach targeting HMGB1 in the treatment of bacterial sepsis and septic shock - Natalie Stevens
• Pulmonary viral infection triggers distal interferon signalling in the bone marrow - Sebastian A Stifter
• Intracerebral responses to non-adapted Dengue virus-2 following postglenoid foramen intracranial inoculation - Luan D Vu
• Harbouring a killer: a proteomic approach to comparing host responses to Hendra virus - Amanda P Woon
• The role of reactive oxygen species in cytokine dysregulation following avian influenza H5N1 and H7N9 infection - Siying Ye
• New application of indirect fluorescent antibody technique using latex particles coupled with VT2 for measurement colostral antibody titers - Shizuo Ymamoto
• Network analysis of checkpoint blockade-induced cancer regression identifies synergistic drug combinations - Willem J Lesterhuis
• Binding to DEC-205 enhances the potency of CpG oligonucleotide adjuvants - Jessica Li
• Immune stimulation of mucosal tissue as a potential strategy to protect against pregnancy complications - Naomi M Scott
• HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model - Yuh-Pyng Sher
• Susceptibility to ileitis of SKG mice under germ free conditions and after colonization with a limited bacterial consortium negatively correlates with the proportion of colonic Foxp3⁺ regulatory Tcells - Zaied Bhuyan
• Immune responses to respiratory virus are deficient in rats with high risk for allergic airways disease. - Anya C Jones
• Peripheral T cell subsets in carriers of the cystic fibrosis transmembrane conductance regulator mutation - Emily Mulcahy
• Oral immunisation with adjuvant X induces an effective mucosal immune response that protects mice against intravaginal HSV-2 challenge - Peter Mulvey
•  Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice - Ji-Hwan Ryu
• Targeting immunogenic peptides from Mycobacterium tuberculosis to TLR2 for use as pulmonary vaccines - Anneliese Ashhurst
• Evaluation of immunogenicity and protective efficacy of engrafted Leishmania-derived plasma membrane vesicles into liposomes - Eskandar Kamali Sarvestani
• Chitosan hydrogel vaccine generates CD8⁺ T cell memory protective in a mouse tumour model - Roslyn A Kemp
• Sequential boosting with recombinant influenza viruses as tuberculosis vaccines - Heni Muflihah
• Transcriptional profiling of immune cell subsets in the draining lymph nodes of mice after vaccination with ISCOMATRIX® adjuvant reveals novel aspects of the mechanism of action - Anne Walter
• Primary immune responses to vaccinia virus vaccination: role of cytotoxic effector CD4+ T cells in the generation of human T cell memory - Cynthia Mee Ling Munier
• Fine-tuning of the CD8 co-receptor via a histone acetyltransferase determines memory T cell potential  - Dane M Newman
• Investigating the role of Eomesodermin in the maintenance and/or programming of virus-specific memory CD8 T cells - Julia E Prier
• How apoptosis shapes regulatory T cell development in the thymus - Charis Teh
• TRAF2 regulates peripheral CD8⁺ and NK T cell homeostasis by modulating sensitivity to IL-15. - Jeanette E Villanueva
• Thymic epithelial membrane antigen abundance dictates the routes available for MHCII-mediated central tolerance - Jin Yan Yap
• Investigating the role of BAFF/BAFF-R signalling in regulating the Germinal Centre Reaction - Wing Yin Angelica Lau
• Circulating human CD27-IgA+ memory B cells recognize bacteria with polyreactive immunoglobulins - Menno C. van Zelm
• IL-27 signaling in human B cell populations enhances their differentiation to Germinal Centre B cells  - Dipti Vijayan
• Cooperation between MYD88 and CD79B mutations for B cell survival and break of tolerance - James Q. Wang
• CD8α⁺ DC-B cell interaction mediated by targeted delivery of antigen to Clec9A - Yu Kato
• The dendritic cell receptor Clec9A: DAMP recognition and immune modulation - Mireille H Lahoud
• CD302 is a C-type lectin receptor involved in the migration of dendritic cells and other myeloid populations. - Kevin Lo
• The physiological role of polycomb group protein Ezh2 in Langerhans cell - Jia Tong Loh
• The impact of vitamin D on synovial dendritic cells in patients with inflammatory arthritis - Mahin Moghaddami
• Targeting antigen to human CD141⁺ DC via CLEC9A results in superior cross-presentation to CD8⁺ T cells compared with targeting DEC-205. - Kristen J Radford
• Persistent and compartmentalised derangement of dendritic cell subsets in the respiratory tract of mice following adult and early-life Influenza A virus infection - Phil Stumbles
• CD83 targeting for specific immunosuppression in allogeneic haematopoietic stem cell transplantation. - Nirupama D Verma
• A preliminary investigation of microRNAs in cerebrospinal fluid samples from patients with chronic fatigue syndrome/ myalgic encephalomyelitis - Sharni L Hardcastle
• FETAL IMMUNE CHANGES IN PRE-ECLAMPSIA REFLECT A BREAKDOWN IN IMMUNE TOLERANCEAltered composition of cord blood T cell subsets in preeclampsia - Mingjing Hu
• IL-4 stimulated mast cells activate immunoregulatory B cells in a contact independent manner involving microparticles - Felix Marsh-Wakefield
• Regulatory T cells in amyotrophic lateral sclerosis and the mSOD1 model: a role in disease modulation? - Fiona McKay
• Transplantation of mesenteric lymph nodes from mice treated with a hookworm protein protects recipients from allergic asthma - Severine Navarro
• Identification of gene signatures associated with Tfh cell localisation during evolution of the adaptive immune response using non-negative matrix factorisation of single-cell gene expression data - Akira Nguyen
• Dopamine within the germinal centre: a new ‘language’ between T and B cells - Ilenia Papa
• Helicobacter pylori induced immune modulation - Senta M Walton

Gang Liu
Fibulin-1 plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD) id# 20884

Alanna Cameron
BRAF inhibitors enhance anti-tumour immune responses in a BRAFV600E melanoma model id# 21061

Alison West
Antagonism of IAPs enhances growth of a myc-driven lymphoma and promotes LPS-mediated sepsis in vivo. id# 20905

Cameron Field
Blockade of CTLA-4, but not PD-1, combined with an autologous tumour cell vaccine, mediates rejection of established glioma id# 20909

Beatrice Nagaria
Alveolar macrophages show delayed upregulation of miRNA expression following M. tuberculosis infection id# 20886

Sebastian Stifter
Pulmonary viral infection triggers distal interferon signalling in the bone marrow id# 21107

Marie Greyer
CD25 expression as a means through which DC integrate T cell help and IL-15 dependent signals into antiviral CD8+ T cell responses id# 20723

Mehdi Rasoli Pirozyan
CD8+ T cell exhaustion during early primary hepatitis C infection in human id# 20970

Natalie Stevens
Evaluation of a novel passive immunotherapy approach targeting HMGB1 in the treatment of bacterial sepsis and septic shock id# 21046

Topic: "Immunologists should be forced to retire at 60”

Moderator: Lynn Corcoran

The negative team is: 
Captain Elissa Deenick
David Tscharke
Anne La Flamme

The affirmative team is:
Captain Nick King
Anne Kelso
Ranjeny Thomas