Wednesday, 3rd December Australasian Society for Immunology Annual Scientific Meeting 2014

Sponsored by CTI

• Consequences of host Microbiota interaction for tissue specific immunity  - Yasmine Belkaid
• Rab and PI3K regulation of TLR signaling and inflammatory cytokines - Jennifer L Stow
• The role of inflammation in tuberculosis - Andrea M Cooper
• Manipulation of dendritic cells:  A tale of two viruses - Anthony L Cunningham

• Regulating immunity in the allergic lung - Clare Lloyd
• Molecular mechanisms underlying the negative regulation of mast cell function - Michele Grimbaldeston
• Power to the peptide – postnatal development of soluble antimicrobial defences of the infant gut and blood - Andrew Currie
• In vivo analysis of mast cell homeostasis in the skin - Ben Roediger

• IFN control of lipid metabolism in macrophages: A mechanistic unravelling of a central immune-metabolic axis in innate-immunity - Peter Ghazal
• Role of microRNA in the regulation of inflammation and host defence in respiratory disease - Paul Foster
• STAT3 controls the differentiation and function of unconventional T cells - Elissa K Deenick
• Endogenous IL-22 is an intrinsic suppressor of β-cell ER stress and islet inflammation and exogenous IL-22 restores glycaemic control in obesity - Sumaira Hasnain

• Revisiting the arthritogenic peptide theory - the link between HLA B27 and autoimmunity - Anthony W Purcell
• Virus antigen presentation on MHC I is complex and poorly reflected in the anti-viral CD8⁺ T cell response - David C Tscharke
• Mechanisms of induction of paralysed dendritic cells with poor antigen presentation function following systemic inflammatory response syndrome - Jose A Villadangos
• The length and biophysical properties of the peptide in the MHC groove predicts T cell receptor repertoire formation - John Miles
• Determining key human mucosal dendritic cell subsets in transfer of HIV-1 to T cells - Andrew Harman
• In vivo priming requirements for CD8⁺ T cells during peripheral Herpes Simplex Virus Type 1 infection - Christina Tebartz
• RUNX2 is essential for plasmacytoid dendritic cell homeostasis - Michael Chopin
• Dendritic cell development is dependent on Drosha-mediated cleavage of mRNAs encoding inhibitors of myelopoiesis - Timothy M Johanson

• Mast cells are required for protection from itching - Scott N Byrne
• MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying PI3K-mediated suppression of HDAC2 - Richard Kim
• Granzyme B facilitates cytotoxic lymphocyte homing via basement membrane remodeling     - Marcia Munoz
• A20 as a master regulator of tissue intrinsic inflammation - Nathan W Zammit
• Characterization of human-restricted TLR4 responses identifies a novel ubiquitin ligase required for NLRP3 inflammasome responses in human macrophages - Juliana K Ariffin
• CCR2 drives CCR6-independent recruitment of 'pathogenic' TH17 cells to the inflamed CNS - Ervin Kara
• The tetraspanin CD53 regulates L-selectin expression, lymphocyte homing and inflammation through a metalloproteinase-dependent mechanism - Maria Demaria
• Mechanism of action of atypical antipsychotics during experimental autoimmune encephalomyelitis - Pirooz Zareie

• Untangling B cell histories and class switch lineages by analysis of murine VDJ gene mutations - Andrew M. Collins
• Expression of IgD on mature lymphocytes is dependent on zinc-finger protein ZFP318 - Anselm Enders
• Complete degradation of CD74-invariant chain by the endopeptidase SPPL2A is necessary for B cell responsiveness and survival - Hannes Bergmann
• Fas mutation liberates rogue germinal centre B cells to produce aberrant IgG and IgE antibodies - Danyal Butt
• The regulation of positive selection and differentiation in the germinal centre response - Dan Suan
• Regulation of T-dependent antibody responses by STAT3  - Alisa Kane
• Analysis of mutations in immunoglobulin genes suggests the existence of intrinsic B cell class switch pathways - Yan Wang
• An essential role for Id proteins and E protein transcription factors in the humoral immune response - Renee Gloury

• Redirecting immune subsets through genetic manipulation for enhancing adoptive immunotherapy. - Carmen SM Yong
• Exploiting skin dendritic cells to influence vaccine-induced immunity - Kerrie Sandgren
• Combination of an NKT cell adjuvant-based cancer vaccine with agonistic anti-4-1BB antibody drives potent anti-tumor immunity against B cell lymphomas - Stephen Mattarollo
• Anti-cancer vaccination using mRNA loaded CMRF-56 immune selected blood dendritic cells - Michael S Papadimitrious
• Targeting liver macrophages with curcumin and regulatory T cells protects mice from diet induced nonalcoholic steatohepatitis - Muralidhara Rao Maradana
• Improving humoral vaccines: exploiting pre-existing, non-cognate, CD4+ T cell help to enhance antibody responses - Tom Hills
• Exploiting bacterial metabolism for developing better vaccines: an interplay between Salmonella growth and immunity - Nancy Wang
• Synthesis and immunological evaluation of self-adjuvanting conjugate cancer vaccine candidates - David M McDonald

• Influenza A based gene silencing – It’s nothing to be sneezed at. - Leonard Izzard
• Glowing cells light the way – Using genetically modified mice to characterise immunity against hookworm infection. - Ryan Kyle
• Functional and structural insights into a unique SElXy staphylococcal superantigen - Ries Langley
• Respiratory influenza infection during pregnancy impacts upon fetal health via the activation of immune cells in gestational tissues. - Jean-Francois Lauzon-Joset
• Human cytomegalovirus regulates immunomodulatory protein Galectin-1 - Emily A Machala
• Alveolar macrophages show delayed upregulation of miRNA expression following M. tuberculosis infection - Beatrice Nagaria
• Leukocyte involvement in clearance of flavivirus from the encephalitic CNS - Paula Niewold
• An occupying force of memory T cells against Epstein Barr Virus - Mainthan Palendira
• Streptococcal 5’-nucleotidase A (S5nA) – a novel group A streptococcal immune evasion factor - Thomas Proft
• Possible superantigen-mediated skewing of the tonsil TCR Vβ repertoire in recurrent tonsillitis patients - Fiona J Radcliff
• CD8+ T cell exhaustion during early primary hepatitis C infection in human - Mehdi Rasoli Pirozyan
• Hypoxia inducible factor 1α (HIF-1α) regulates anti-inflammatory responses during colitis  - Ellen Marks
• Intestinal inflammation causes aberrant immune cell migration resulting in secondary organ inflammation in inflammatory bowel disease. - Sean W Mateer
• Mechanism of apremilast in atopic dermatitis: normalization of interleukin-4 dysregulation on primary human epidermal cells - Girish C. Mohan
• Development of multi-parameter flow cytometric panels for the evaluation of regulatory T cell subpopulations in inflammatory bowel disease patients of different ethnic and cultural backgrounds - Nazri Mustaffa
• Myeloperoxidase is an immune regulator in the development of experimental lupus - Dragana Odobasic
• Identification of anti-inflammatory compounds from Hookworm excretory/secretory low molecular weight products - Catherine A Shepherd
• A developmental origin to asthma, mediated by dietary metabolites and effects on Foxp3 transcriptional activity - Alison Thorburn
• Unbiased transcriptomes of resting human CD4+CD45RO+ T lymphocytes - Kerstin Westendorf
• Tetraspanin CD37 regulates β2 integrin-mediated adhesion and migration in neutrophils - Mark D Wright
• Activated protein C inhibits inflammation and pathological angiogenesis  and suppresses collagen-induced arthritis - Meilang Xue
• BRAF inhibitors enhance anti-tumour immune responses in a BRAF^V600E melanoma model - Alanna M Cameron
• Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice - Hwan-Suck Chung
• Targeting tumor-induced immunosuppression leads to potent anti-tumor responses by CAR T cells - Phil K Darcy
• Blockade of CTLA-4, but not PD-1, combined with an autologous tumour cell vaccine, mediates rejection of established glioma - Cameron S Field
• In the fight against brain cancer, not all “off” switches are created equal - Cameron S Field
• Impact of human plasma components on the functionality of human monocyte-derived dendritic cells generated for immunotherapeutic purposes - Olivier Gasser
• Large-scale isolation of highly pure untouched regulatory T cells in a GMP environment for adoptive cell therapy - Doreen Haase
• Mechanism of HIV induction of interferon stimulated gene in macrophages in the absence of interferon production - Najla Nasr
• Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus Influenzae (NTHi) from infected lung - Hock L Tay
• Characterising natural killer cell subset responses to a Herpes Simplex Virus lipopeptide - Naomi Truong
• Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection - Paul G Whitney
• MicroRNA-487b contributes to macrophage homeostasis by targeting interleukin-33 - Ming Yang
• CD4 T cells can mediate both tumour clearance and tumour escape in the absence of direct tumour antigen recognition - Elena Shklovskaya
• Eradication of established orthotopic Her2⁺ tumours using dual-specific T cells and vaccine - Clare Y Slaney
• T cells are functionally and phenotypically suppressed in colorectal cancer tissue. - Edward Taylor
• Changes in the tumour microenvironment during CD4+ T cell mediated tumour rejection - Alexandra Terry
• Tracking T cell migration during tumour responses - Tommaso Torcellan
• Comparative immune phenotypic analysis of cutaneous squamous cell carcinoma and intraepidermal carcinoma in immune-competent individuals: proportional representation of CD8⁺ T-cells but not FoxP3⁺ Regulatory T-cells is associated with disease stage. - James W Wells
• Antagonism of IAPs enhances growth of a myc-driven lymphoma and promotes LPS-mediated sepsis in vivo. - Alison C West
• CD4+ help for CD8+ T cells at the transcriptional level - Hayley A Croom
• Characterisation of bone marrow CD8+ memory T cells - Jolie Cullen
• Genetics controlling NKT cell development - Xuyen Dinh
• Therapeutic deletion of IL-17 producing CD8+ T cells (Tc17) attenuates GVHD without impairing GVL - Kate H Gartlan
• CD8+ memory T cells: Ready! Set! Go? - Susanne Heinzel
• Regulation of effector CD4⁺ and CD8⁺ T cell function during HSV infection - Bethany L Macleod
• Mapping the functionall role of micro RNAs in human  regulatory T cell subsets - Simon Barry
• Peptidase inhibitor 16 identifies antigen experienced resting memory T helper cells with potent effector function - Simon Barry
• Phenotypical and functional characterization of innate-like T cells in cancer patients - Yosuke Minoda
• MARCH more than complimentary: Novel substrate partners of MARCH-1 in plasma membrane regulation on B cells - Alan Ching
• Improving the in vitro culture conditions for the study of circulating B cell antibody specificity repertoire - Plinio R Hurtado
• Characterisation of an ENU-induced gain-of-function Card11 mouse strain as a model for human B cell diseases - Yogesh Jeelall
• Expression of the chemokine receptor XCR1 characterizes the cross-presenting lineage of dendritic cells in mouse and men - Annabell Bachem
• Phenotyping dendritic cell subsets from human anogenital tissues - Rachel Botting
• TAM receptors are a novel regulatory pathway on human plasmacytoid dendritic cells modulating survival, activation and cytokine secretion - Christian Bryant
• Variable resistance to glucocorticoids reveals distinct human and murine plasmacytoid dendritic cell subsets - Christian E Bryant
• Determining the role of DEC-205 and CD14 in the recognition of CpG DNA. - Irina Caminschi
• Deciphering the nature and function of intestinal APC in the priming of mucosal immunity - Lisa Connor
• Testing a panel of antibodies directed to DC surface proteins on dermal dendritic cells - Andrew Harman
• Characterization of the role of the MARCH family of ubiquitin ligases on membrane proteostasis in vivo by proteomic analysis - Pauline PY Huang
• Follicular Helper T cells induce differentiation CD14+ monocytes into dendritic cells like via IL-21 - Plinio R Hurtado
• Regulatory T cell trafficking in human health and immuno-inflammatory disease - Suzanne Asad
• Regulatory T cells modulate DC function to prevent pathogenic T cell responses during immune reconstitution - Holly Bolton
• Treg-derived soluble CTLA-4 regulates dendritic cell CD80/CD86 and the T cell activation threshold in vivo - Holly Bolton
• Uncovering new pathways of CD8 T-cell regulation in the skin  - Jennifer A Bridge
• Foxp3⁺ Tregs require RelA to prevent autoimmunity. - Thomas Fulford
• Effects of plasma components from Naïve and West Nile virus-infected mice on cellular uptake of immune-modulating microparticles. - Darren A Cox
• Effect of mutations in PI3 kinase p110d on the phenotype and function of EBV-specific human CD8+ T-cells  - Emily SJ Edwards
• CD25 expression as a means through which DC integrate T cell help and IL-15 dependent signals into antiviral CD8⁺ T cell responses  - Marie Greyer

• MicroRNA-146a limits T follicular helper cell and germinal center B cell numbers - Alvin Pratama
• NK cells require IFN type III for in vivo effector functions - Fernando Guimaraes
• Antigen expression level dictates the outcome of CD8⁺ T cell responses against antigens expressed in the liver - Yik Chun (Michael) Wong
• The role of TLR2 signaling in gastric cancer - Alison C West
• Programming T cell division number: It's as easy as 1 + 2 + 3 - Julia M Marchingo
• Collaboration and cross-talk between CD4 T cells and ILC2s maintain protective immune responses against hookworm infection - Ryan Kyle